The Continuous Monitoring / Peeking Problem & Mixture Sequential Probability Ratio Test (mSPRT) establishes rigorous martingales-based defenses against false-positive rate inflation during continuous experimental monitoring; Peeking Pathology: repeatedly computing
p-values daily and terminating early upon reaching
p<0.05 inflates the nominal
5% false positive rate to
$>30-40\%$ within 30 days under the null hypothesis $H_0$ due to random walk fluctuations crossing critical boundaries; Statistical Remedies: 1) Pre-registered Fixed-Horizon Testing (enforcing full-duration runs); 2) Group Sequential Boundaries (O'Brien-Fleming / Pocock alpha-spending functions); 3) Continuous Sequential Testing via mSPRT (constructing martingale-based Always-Valid
p-values and time-uniform Confidence Sequences) enabling safe continuous monitoring and anytime early stopping.